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Drug companies favor biotech meds over pills, citing new U.S. law

By Deena Beasley San Francisco (Reuters) - Drugmakers are prioritizing complex biotech medicines over treatments that can be given as pills because recent U.S. legislation gives...
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By Deena Beasley

San Francisco (Reuters) - Drugmakers are prioritizing complex biotech medicines over treatments that can be given as pills because recent U.S. legislation gives biologics a longer runway before becoming subject to government price limits, top industry executives said this week.

The Inflation Reduction Act (IRA), which Democrats passed last August, for the first time allows the government's Medicare health plan for people age 65 and over to negotiate the prices it is willing to pay for certain medications.

The pharmaceutical industry, whose members gathered in the thousands this week in San Francisco for the annual JP Morgan Healthcare conference, opposed the legislation and has begun implementing strategies to mitigate its impact.

Such a shift in focus could result in the availability of far fewer cheap, generic pills in the long run.

All other developed nations negotiate drug prices, making the United States the most lucrative market for the industry. The Congressional Budget Office estimates that the IRA's drug pricing provisions will reduce the federal deficit by $237 billion over the next decade.

Medicare will select the first 10 drugs for the program this year. The number of medications subject to price negotiation will increase over time, but newer drugs are not included.

The law sets a nine-year exemption period for "small-molecule" drugs, which are mainly pills, while "large molecule" biologics, generally injections or infusions, are protected from negotiation for 13 years.

"The difference between a nine- and 13-year product line is about 50 or 60% of the value," Eli Lilly (NYSE:LLY) Chief Executive Officer Dave Ricks said in an interview. "In 10 years, we'll have far fewer small molecules being developed than we do today."

He questioned the benefit of "rules that really just disincentivize investment in what ends up being convenient drugs, drugs for tough conditions like cancer and drugs that get really cheap when they go generic."

Lilly has already dropped a small-molecule blood cancer drug from its pipeline because "we just couldn't make the math work," Ricks said.

The Indianapolis-based company is considering culling more early-stage pill programs and is directing its small molecule development group to only pursue opportunities "that would be clearly good enough within nine years to be winners."

U.S. Congresswoman Katie Porter, a Democrat who has pressed for drug price limits, described the companies' strategy for dealing with the law as "treating potential new drugs as bargaining chips instead of as cures to save lives."

Most medicines on the market today are small molecules, which can be taken by mouth, absorbed into the bloodstream and easily penetrate cell membranes. Common examples include aspirin, statins for high cholesterol and blood pressure drugs.

In recent decades, pharmaceutical development has moved into more complex, difficult to manufacture large molecules, derived from living cells that can target a specific location or mechanism in the body. These biologics, like AbbVie (NYSE:ABBV)'s rheumatoid arthritis drug Humira, need to be injected or infused and can require special handling or monitoring of patients.

But the industry has also come up with innovative pills, which patients often prefer. Lilly and other drugmakers, for instance, are developing oral drugs for a diabetes and obesity- related target that is currently reached only by injected drugs.

'UNINTENDED CONSEQUENCES'

When pills lose patent protection, generic copies usually enter the market at price discounts of up to 90%, while the competing "biosimilar" versions of large molecule drugs is much less robust and the discounts much lower.

Steven Pearson, president of the influential drug pricing research group Institute for Clinical and Economic Review, said the IRA overall should help lower prices for Medicare patients but acknowledged new laws like it can have "unintended consequences."

He noted it is not unusual for pharmaceutical companies to choose not to pursue a drug they once thought promising.

"We have only made it more complicated now," he said.

Stephen Ubl, president of Pharmaceutical Research and Manufacturers of America (PhRMA), said the industry trade group believes the IRA should not set different exemption periods based on drug type. "We would like that provision to be fixed," he said.

Executives at U.S. biotech Amgen Inc (NASDAQ:AMGN) said the IRA will have broad industry impact, but that Amgen is well-positioned for growth due to its strong position in biologics.

"Large molecules are relatively favored under the IRA as opposed to small molecules," David Reese, head of Amgen research and development, said in an interview. "Given our history and our focus in protein therapeutics, that's one advantage."

PhRMA said that when asked in a recent survey if they expect to shift research and development investment away from small molecule medicines, 63% of member companies who responded to the question said yes.

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29-01-2023 23:11:22 (UTC+7)

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    EUR/USD 1.0869 ↑ Buy  
    GBP/USD 1.2399 ↑ Buy  
    USD/JPY 129.85 Buy  
    AUD/USD 0.7108 ↑ Sell  
    USD/CAD 1.3311 Neutral  
    EUR/JPY 141.14 ↑ Buy  
    EUR/CHF 1.0015 ↑ Buy  
    Gold 1,928.00 ↑ Sell  
    Silver 23.725 ↑ Buy  
    Copper 4.2300 ↑ Buy  
    Crude Oil WTI 79.38 ↑ Sell  
    Brent Oil 86.40 ↑ Sell  
    Natural Gas 2.856 ↑ Sell  
    US Coffee C 169.25 Sell  
    Euro Stoxx 50 4,178.01 ↑ Buy  
    S&P 500 4,070.56 ↑ Sell  
    DAX 15,150.03 ↑ Buy  
    FTSE 100 7,765.15 ↑ Buy  
    Hang Seng 22,688.90 Buy  
    Small Cap 2000 1,911.46 ↑ Sell  
    IBEX 35 9,060.20 ↑ Buy  
    BASF 52.790 ↑ Buy  
    Bayer 56.28 ↑ Buy  
    Allianz 221.65 ↑ Buy  
    Adidas 148.30 Sell  
    Lufthansa 9.755 ↑ Buy  
    Siemens AG 144.50 ↑ Buy  
    Deutsche Bank AG 12.340 ↑ Buy  
Mua/Bán 1 chỉ SJC
# So hôm qua # Chênh TG
SJC Eximbank6,720/ 6,820
(6,720/ 6,820) # 1,331
SJC HCM6,720/ 6,820
(-20/ -20) # 1,331
SJC Hanoi6,720/ 6,822
(-20/ -20) # 1,333
SJC Danang6,720/ 6,822
(-20/ -20) # 1,333
SJC Nhatrang6,720/ 6,822
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SJC Cantho6,720/ 6,822
(-20/ -20) # 1,333
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Ngoại tệMua vàoBán ra
USD23.260,0023.630,00
EUR24.857,5526.249,47
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JPY175,71186,02
KRW16,4320,02
Cập nhật lúc 18:54:06 29/01/2023
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